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MOLECULAR BIOLOGY & GENETICS PROGRAM

PROGRAM OVERVIEW

Michael Lisanti, M.D., Ph.D., Program Leader
Bruno Calabretta, M.D., Program Co-Leader

The Molecular Biology and Genetics Program of the Kimmel Cancer Center is composed entirely of NIH funded investigators with interests in the basic processes involved in tumorigenesis.

Fishel, R. (1999): Signaling mismatch repair in cancer. Nature Medicine (N&V), 5, 1239-1241.

The goal of the Program is to coordinate and integrate fundamental studies on the genes and associated molecular processes involved in tumorigenesis and viral pathogenesis with Clinical translational programs. It is now well known that the development of cancer requires the alteration of dozens of genes and cellular processes. Furthermore, the process of viral pathogenesis alters normal cellular functions which can lead to cancer as well as other viral associated diseases. Indeed, the first cancer genes were found to be carried by oncogenic tumor viruses. Basic research on the genetics and molecular biology of these processes has lead to a new understanding of carcinogenesis and viral pathogenesis and resulted in the rapid development of new clinical protocols. The members of the Program have a long and productive track record studying many of these processes and translating that work into both a clinical and preventional setting.

Molecular Biology and Genetics Program Faculty

Arthur Buchberg, Ph.D.

Associate Professor, Microbiology & Immunology

Program Member

Dr. Buchberg's PubMed

Bruno Calabretta, M.D., Ph.D.

Professor, Cancer Biology

Program Co-Leader

Dr. Calabretta's PubMed

Susan K. Gilmour, Ph.D.

Lankenau Institute for Medical Research

Program Member

Dr. Gilmour's PubMed

James B. Jaynes, Ph.D.

Associate Professor, Biochemistry and Molecular Biology

Program Member

Dr. Jaynes's PubMed

Erik Knudsen, Ph.D.

Professor, Cancer Biology

Program Member

Dr. Knudsen's PubMed

Michael Lisanti, M.D., Ph.D.

Professor, Cancer Biology

Program Leader

Dr. Lisanti's PubMed

Alexander M. Mazo, Ph.D.

Professor, Biochemistry and Molecular Biology

Program Member

Dr. Mazo's PubMed

Steven McMahon, Ph.D.

Associate Professor, Cancer Biology

Program Member

Dr. McMahon's PubMed

W. Edward Mercer, Ph.D.

Professor, Microbiology & Immunology

Program Member

Dr. Mercer's PubMed

Marja Nevalainen, M.D., Ph.D.

Associate Professor, Cancer Biology

Program Member

Dr. Nevalainen's PubMed

Thomas G. O'Brien, Ph.D.

Lankenau Institute for Medical Research

Program Member

Dr. O'Brien's PubMed

John M. Pascal, Ph.D.

Assistant Professor, Biochemistry and Molecular Biolgy

Program Member

Dr. Pascal's PubMed

Linda D. Siracusa, Ph.D

Associate Professor, Microbiology & Immunology

Program Member

Dr. Siracusa's PubMed

Jouni J. Uitto, M.D., Ph.D.

Professor, Dermatology and Cutaneous Biology

Program Member

Dr. Uitto's PubMed

The program members' publications in 2005 and 2006

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