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KCC Discovery Core

The KCC Discovery Core consists of liquid handling and multiwell detection instrumentation to facilitate discovery of chemical or genetic effectors of biological pathways from arrayed libraries. The resource includes a Biomek 2000 arraying robot housed in a Baker SG-603a reinforced biosafety cabinet and a BMG POLARstar Optima multifunction plate reader (UV/vis, fluorescence intensity, fluorescence anisotropy, time-resolved fluorescence & luminescence).

A library of more than 30,000 compounds is available as a source of molecular diversity for discovery of chemical effectors of biological targets. In addition, resource equipment can be used by KCC members to array sources of molecular diversity that they obtain independently (for example, si- or shRNA libraries or plated screening sets from the Developmental Therapeutics Program of the National Cancer Institute).

Contact Michael McCauley (3-4574) or Dr. Scott (3-4569) to obtain arrayed compounds, arrange for training or consult on assay design.