Publications

  1. Hou, YM, Perona, JJ. (2004) "Cysteinyl-tRNA synthetase" in "The aminoacyl-tRNA synthetases", edited by Ibba M, Francklyn, C, and Cusack, S, Landes Bioscience Publishing, in press.
  2. Ougland, R, Zhang, CM, Johansen, RF, Seeberg, E, Hou, YM, Remme, J, Falnes, PO. (2004) "AlkB restores the biological function of mRNA and tRNA inactivated by chemical modification", Mol. Cell, in press.
  3. Gamper, HB, Gerwirtz, A, Hou, YM. (2004) "Modified bases in RNA reduce secondary structure and enhance hybridization", Biochemistry, 43, 10224-10236.
  4. Christian, T, Evilia, C, Williams, S, Hou, YM. (2004) "Distinct origins of tRNA(m1G37) methyl transferase", J. Mol. Biol. 339, 707-719.
  5. Zhang, CM, Hou, YM. (2004) "Synthesis of cysteinyl-tRNACys by a prolyl-tRNA synthetase", RNA biology, 1, 35-41.
  6. Rajanna, C, Wang, J, Zhang, D, Xu, Z, Ali, A, Hou, YM, Karaolis, DKR. (2003) "The Vibrio pathogenicity island forms precise extrachromosomal circular excision products", J. Bacteriology, 185, 6893-6901.
  7. Zhang, CM, Newberry, KJ, Perona, JJ, Hou, YM. (2003) "Amino acid discrimination by a highly differentiated metal center of an aminoacyl-tRNA synthetase", Biochemistry, 42, 10931-10937.
  8. Evilia, C, Ming, XT, DasSarma, S, Hou, YM. (2003) "Aminoacylation of an unusual tRNA from an extreme halophile", RNA, 9, 794-801.
  9. Lipman, RSA, Chen, C., Evilia, C., Vitseva, O., Hou, YM. (2003) "Association of an aminoacyl-tRNA synthetase with a metabolic protein in Archaea" Biochemistry, 42, 7487-7496.
  10. Zhang, CM, Christian, T, Newberry, KJ, Perona, JJ, Hou, YM. (2003) "Zinc mediated amino acid discrimination in cysteinyl-tRNA synthetase", J. Mol. Biol., 327, 911-917.
  11. Francklyn, C, Perona, JJ, Putz, J, Hou, YM. (2002) "Aminoacyl-tRNA synthetases: Versatile players in the changing theater of translation", RNA, 8, 1363-1372.
  12. Newberry, KJ, Hou, YM, Perona, JJ. (2002) "Structural origins of amino acid selection without editing by cysteinyl-tRNA synthetase", EMBO J., 21, 2778-2787.
  13. Ming, XT, Smith, K, Suga, H, Hou, YM. (2002) "Recognition of tRNA backbone for aminoacylation with cysteine: Evolution from E. coli to human", J. Mol. Biol., 318, 1207-1220.
  14. Hou, YM. (2002) "Base-pairing in tRNA: Unusual patterns", Encyclopedia of Life Sciences, http://www.els.net. London:Nature Publishing Group.
  15. Seth, M, Thurlow, DL, Hou, YM. (2002) "Poly(C) synthesis by class I and class II CCA-adding enzymes", Biochemistry, 41, 4521-4532.
  16. Lipman, RSA, Beuning, PJ, Musier-Forsyth, Hou, YM. (2002) "Amino acid activation of a dual-specificity tRNA synthetase is independent of tRNA", J. Mol. Biol. 316, 421-427.
  17. Lipman, RSA, Wang, JL, Sowers, KR, Hou, YM. (2002) "Prevention of misaminoacylation of a dual-specificity aminoacyl-tRNA synthetase", J. Mol. Biol. 315, 943-949.
  18. Tardif, K, Liu, MS, Vitseva, O, Hou, YM, Horowitz, J. (2001) "Misacylation by E. coli valyl-tRNA synthetase: Evidence for two tRNA binding sites", Biochemistry 40, 8118-8125.
  19. Burke, B, Lipman, RSA, Shiba, K, Musier-Forsyth, K, Hou, YM. (2001) "Divergent adaption of recognition of tRNAPro by Methanococcus jannaschii prolyl-tRNA synthetase", J. Biol. Chem. 276, 20286-20291.
  20. Hou, YM, Zhang, XL, Holland, JA, Davis, DR. (2001) "An important 2'-OH group for an RNA-protein interaction", Nucleic Acids Res. 29, 976-985.
  21. Davidson, E, Caffarella, J, Vitseva, O, Hou, YM, King, MP. (2001) "Isolation of two cDNAs encoding functional human cytoplasmic cysteinyl-tRNA synthetase", Biological Chemistry 382, 399-406.
  22. Gamper, HB, Hou, YM, Kmiec, EB. (2000) "Evidence for a four-strand exchange catalyzed by the RecA protein", Biochemistry 39, 15272-15281.
  23. Christian, T, Lipman, RSA, Evilia, C, Hou, YM. (2000) "Alternative design of a tRNA core for aminoacylation", J. Mol. Biol. 303, 503-514.
  24. Hou, YM. (2000) "Unusual synthesis by the E. coli CCA-adding enzyme", RNA 6, 1031-1043.
  25. Lipman, RSA, Sowers, KR, Hou, YM. (2000) "Synthesis of cysteinyl-tRNACys by a genome that lacks the normal cysteine-tRNA synthetase", Biochemistry 39, 7792-7798.
  26. Hou, YM, Sundaram, M, Zhang, XL, Holland, JA, Davis, DR. (2000) "Recognition of functional groups in an RNA helix by a class I tRNA synthetase", RNA 6, 922-927.
  27. Madore, E, Lipman, RSA, Hou, YM, Lapointe J. (2000) "Evidence for unfolding of the single-stranded GCCA 3'-end of a tRNA on its aminoacyl-tRNA synthetase from a stacked helical to a fold-back conformation", Biochemistry 39, 6791-6798.
  28. Sherlin, LD, Bullock, TL, Newberry, KJ, Lipman, RSA, Hou, YM, Beijer, B, Sproat, BS, Perona, JJ. (2000) "Influence of transfer RNA tertiary structure on aminoacylation efficiency by glutaminyl and cysteinyl-tRNA synthetases", J. Mol. Biol. 299, 431-446.
  29. Hamann, CS, Hou, YM. (2000) "Probing a tRNA core that contributes to aminoacylation", J. Mol. Biol. 295, 777-789.
  30. Hou, YM, Motegi, H, Lipman, RSA, Hamann, CS, Shiba, K. (1999) "Conservation of a tRNA core for aminoacylation", Nucleic Acids Res 27, 4743-4750.
  31. Hou, YM. (1999) "Contribution of a tRNA core to aminoacylation: the role of a proposed adenosine base triple in aminoacylation with cysteine", Nucleic Acids Sym.Series 41, 208-210.
  32. Holland, JA, Hou, YM, Davis, DR. (1999) "NMR structural studies of the tRNACys amino acceptor stem of Mycoplasma pneumonia", Nucleic Acids Sym Series 41, 101-103.
  33. Hamann, CS, Sowers, KR, Lipman, RSA, Hou, YM. (1999) "An archaeal aminoacyl-tRNA synthetase missing from genomic analysis", J. Bacteriology 181, 5880-5884.
  34. Hou, YM. (1999) "Transfer RNAs and pathogenicity islands", Trends in Biochemical Sciences 24, 295-298.
  35. Newberry, KJ, Kohn, J, Hou, YM, Perona, JJ. (1999) "Crystallization and preliminary diffraction analysis of Escherichia coli cysteinyl-tRNA synthetase", Acta Cryst. D. D55, 1046-1047.
  36. Lipman, RSA, Hou, YM. (1998) "Aminoacylation of tRNA in the evolution of an aminoacyl-tRNA synthetase", Proc. Natl. Acad. Sci. USA. 95, 13495-13500.
  37. Hou, YM, Lipman, RSA, Zarutskie, JA. (1998) "A tRNA circularization assay: Evidence for the variation of the conformation of the CCA end", RNA 4, 733-738.
  38. Gamper, HB, Stamm, MR, Meyer, RB, Hou, YM. (1998) "Targeted D-loop formation in supercoiled DNA by chimeric oligonucleotides",J. Am. Chem. Society 120, 2128-2183.
  39. Hamann, CS, Hou, YM. (1997) "A strategy of tRNA recognition that includes determinants of RNA structure", Bioorganic & Medicinal Chemistry 5, 1011-1019.
  40. Hamann, CS, Hou, YM. (1997) "An RNA structural determinant for tRNA recognition", Biochemistry 36, 7967-7972.
  41. Hou, YM. (1997) "Discriminating among the discriminator bases of tRNAs", Chem& Biol 4, 93-96.
  42. Hou, YM, Gamper, H. (1996) "Inhibition of tRNA aminoacylation by 2'-O-methyl oligonucleotides", Biochemistry 35, 15340-15348.
  43. Ohannesian, DW, Oh, J, Hou, YM. (1996) "Mutational analysis of a leucine heptad repeat motif in a class I tRNA synthetase", Biochemistry 35, 14405-14412.
  44. Sterner, T, Jansen, M, Hou, YM. (1995) "Structural and functional accommodation of nucleotide variations at a conserved tRNA tertiary base pair", RNA 1, 841-851.
  45. Hou, YM, Sterner, T, Bhalla, R. (1995) "Evidence for a conserved relationship between an acceptor stem and a tRNA in aminoacylation", RNA 1, 707-713.
  46. Hou, YM. (1995) "RNA recognition based on a pair of tertiary hydrogen interaction", Nucleic Acids Research Symposia Series 33, 172-175.
  47. Hamann, CS, Hou, YM. (1995) "Enzymatic aminoacylation of tRNA acceptor stem helices with cysteine is dependent on a single nucleotide", Biochemistry 34, 6527-6532.
  48. Hou, YM, Sterner, T, Jansen, M. (1995) "Permutation of a pair of tertiary nucleotides in a transfer RNA", Biochemistry 34, 2978-2984.
  49. Hou, YM. (1994) "Structural elements that contribute to an unusual tertiary interaction in a transfer RNA", Biochemistry 33, 4677-4683.
  50. Hou, YM. (1993) "The tertiary structure of tRNA and the development of the genetic code", Trends In Biochemistry Sciences. 18, 362-364.
  51. Hou, YM, Westhof, E, Giegé, R. (1993) "An unusual RNA tertiary interaction has a role for the specific aminoacylation of a transfer RNA", Proc. Natl. Acad. Sci. USA. 90, 6776-6780.
  52. Hou, YM, Schimmel, P. (1992) "Functional compensation of a recognition-defective transfer RNA by a distal base pair substitution", Biochemistry 31, 10310-10314.
  53. Hou, YM. (1992) "The second genetic code", in Fundamentals of Medical Cell Biology, vol. 4, Chemistry of the Living Cell, JAI press Inc, p. 105-165.
  54. Hou, YM, Schimmel, P. (1992) "Novel tRNAs that are active in E. coli ", Biochemistry 31, 4157-4160.
  55. Miller, WT, Hou, YM, Schimmel, P. (1991) "Mutant aminoacyl tRNA synthetase that compensates for a mutation in the major identity determinant of its tRNA", Biochemistry 30, 2635-2641.
  56. Hou, YM, Shiba, K, Mottes, C, Schimmel, P. (1991) "Sequence determination and modeling of structural motifs for the smallest aminoacyl tRNA synthetase" Proc. Natl. Acad. Sci. USA. 88, 976-980.
  57. Hou, YM, Francklyn, C, Schimmel, P. (1989) "Molecular dissection of a transfer RNA and the basis for its identity", Trends In Biochemistry 14, 233-237.
  58. Hou, YM, Schimmel, P. (1989) "Evidence that a major determinant for the identity of a transfer RNA is conserved in evolution", Biochemistry 28, 6800-6804.
  59. Hou, YM, Schimmel, P. (1989) "Modeling of in vitro kinetic parameters for the elaboration of transfer RNA identity in vivo ", Biochemistry 28, 4942-4947.
  60. Park, SJ, Hou, YM, Schimmel, P. (1989) "A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA", Biochemistry 28, 2740-2746.
  61. Hou, YM, Kim, R, Kim, SH. (1988) "Expression of the mouse metallothionein-I gene in Escherichia coli: increased tolerance to heavy metals. Biochimica et Biophysica Acta, 951, 230-234.
  62. Hou, YM, Schimmel, P. (1988) "A simple structural feature is a major determinant of the identity of a transfer RNA", Nature 333, 140-145.